My mom didn't run for mayor until she was 65 years old - it was like a second and third career.... The way I've always thought about it is that I don't believe you run for office because you want a job. I believe if you run for office, it's because you have a vision for change. And if I ever came to that point, that's what would lead [me to run]. And right now I'm happily in a position where I believe I can work to deliver impact and work for change.

Certainly there was the Affordable Care Act part, then unaccompanied children [there has been a surge of children entering the country illegally and without parents, particularly in Texas], and things like, we find smallpox in an NIH lab, after 50 years? Why didn't you find it, like, five weeks ago or three years ago? There was thing after thing. But the big ones were [dealing with] the Ebola [outbreak], the unaccompanied children. [It was] perhaps a bigger challenge than I had calculated on my yellow pad as I was thinking about this role.

Putting People First was progressivism revived, and at its best.

I had to sign the paper to shut down the government. It's terrible.... [But] what the shutdown showed many, many people is the importance of the role of government. And as frustrated [as people get with] Washington, there are so many things [the government does] that are so important to people's lives every day. The panda cam, paying small businesses their loans - these are all things that shut down.

Can we have a conversation about the substance? That's what I welcome. We're happy to have those conversations if there are places where people think there can be improvements. We want competition in the system, so let's talk about that.

I have been fortunate to work in places where people have a passion for their work. At HHS the passion sort of exceeds passion - it's a vocation.... I obviously knew that there were certainly some challenges that I would be taking on both with the work and the politics. [But] I probably did not have the right expectation level with regard to the number and volume of crises that would occur.

My mom didn't run for mayor until she was 65 years old - it was like a second and third career.... The way I've always thought about it is that I don't believe you run for office because you want a job. I believe if you run for office, it's because you have a vision for change. And if I ever came to that point, that's what would lead [me to run]. And right now I'm happily in a position where I believe I can work to deliver impact and work for change.