I generally disagree with most of the very high margin opportunities. Why? Because it's a business strategy tradeoff: the lower the margin you take, the faster you grow.

Certain food-based biofuels like biodiesel have always been a bad idea. Others like corn ethanol have served a useful purpose and essentially are obsoleting themselves.

No one will pay you to solve a non-problem.

I believe cellulosic fuels, biofuels made from nonfood crops are the only solution that will make a difference.

Letting the perfect be the enemy of the good is one of the reasons we have a coal-dependent infrastructure, with the resulting environmental impact that all of us can see. I suspect environmentalists, through their opposition of nuclear power, have caused more coal plants to be built than anybody. And those coal plants have emitted more radioactive material from the coal than any nuclear accident would have.

For electric power generation, we are very optimistic about solar-thermal technology, and we’re intrigued by the potential of enhanced geothermal energy to replace coal-based power generation. Traditional carbon capture and sequestration-based coal power generation is somewhat unlikely to be competitive.

It doesn't matter what your probability of failure is. If there's a 90% chance of failure, there's a 10% chance of changing the world.