I generally disagree with most of the very high margin opportunities. Why? Because it's a business strategy tradeoff: the lower the margin you take, the faster you grow.

Every big problem is a big opportunity.

I do not know what got me interested in technology. What was very clear to me very early on was that I was not interested in religion and that naturally increased my curiosity about science and technology, and I fundamentally believe the two are conflicting.

The right way to build a company is to experiment in lots of small ways, so that you have plenty of room to make mistakes and change strategies.

The only way you multiply resources is with technology. To really affect poverty, energy, health, education, or anything else - there is no other way.

The state of healthcare today is that we are busy in the practice of medicine vs. being in the science of medicine.

Now it will take a long time to scale biofuels, but I'm the only one in the world forecasting oil dropping in price to $35 a barrel by 2030. I'll put it on the record: Oil will not be able to compete with cellulosic biofuels. If you do it from food, the food will get so expensive you can't make fuel out of it.