A disruption of the circadian cycle—the metabolic and glandular rhythms that are central to our workaday life—seems to be involved in many, if not most, cases of depression; this is why brutal insomnia so often occurs and is most likely why each day’s pattern of distress exhibits fairly predictable alternating periods of intensity and relief.

Through the healing process of time-and through medical intervention or hospitalization in many cases-most people survive depression which may be its only blessing; but to the tragic legion who are compelled to destroy themselves there should be no more reproof attached than to the victims of terminal cancer.

It is hopelessness even more than pain that crushes the soul.

Writing is a form of self-flagellation.

Every writer since the beginning of time, just like other people, has been afflicted by what a friend of mine calls

Depression...so mysteriously painful and elusive.

Perhaps the critics are right: this generation may not produce literature equal to that of any past generation-who cares? The writer will be dead before anyone can judge him-but he must go on writing, reflecting disorder, defeat, despair, should that be all he sees at the moment, but ever searching for the elusive love, joy, and hope-qualities which, as in the act of life itself, are best when they have to be struggled for, and are not commonly come by with much ease, either by a critic's formula or by a critic's yearning.