A disruption of the circadian cycle—the metabolic and glandular rhythms that are central to our workaday life—seems to be involved in many, if not most, cases of depression; this is why brutal insomnia so often occurs and is most likely why each day’s pattern of distress exhibits fairly predictable alternating periods of intensity and relief.

I'm simply the happiest, the placidest, when I'm writing, and so I suppose that that, for me, is the final answer. ... It's fine therapy for people who are perpetually scared of nameless threats as I am most of the time.

The weather of Depression is unmodulated, its light a brownout.

For a person whose sole burning ambition is to write - like myself - college is useless beyond the Sophomore year.

my brain had begun to endure its familiar siege: panic and dislocation, and a sense that my thought processes were being engulfed by a toxic and unnameable tide that obliterated any enjoyable response to the living world.

The pain of severe depression is quite unimaginable to those who have not suffered it.

I thought there's something to be said for honor in this world where there doesn't seem to be any honor left. I thought that maybe happiness wasn't really anything more than the knowledge of a life well spent, in spite of whatever immediate discomfort you had to undergo, and that if a life well spent meant compromises and conciliations and reconciliations, and suffering at the hands of the person you love, well then better that than live without honor.