Depression...so mysteriously painful and elusive.

I think it's unfortunate to have critics for friends.

I'm simply the happiest, the placidest, when I'm writing, and so I suppose that that, for me, is the final answer. ... It's fine therapy for people who are perpetually scared of nameless threats as I am most of the time.

It's fine therapy for people who are perpetually scared of nameless threats as I am most of the time — for jittery people.

In depression . . . faith in deliverance, in ultimate restoration, is absent. The pain is unrelenting, and what makes the condition intolerable is the foreknowledge that no remedy will come - - not in a day, an hour, a month, or a minute . . . It is hopelessness even more than pain that crushes the soul.

A disruption of the circadian cycle—the metabolic and glandular rhythms that are central to our workaday life—seems to be involved in many, if not most, cases of depression; this is why brutal insomnia so often occurs and is most likely why each day’s pattern of distress exhibits fairly predictable alternating periods of intensity and relief.

The stigma of self-inflicted death is for some people a hateful blot that demands erasure at all costs.