[However], the sufferer from depression has no option, and therefore finds himself, like a walking casualty of war, thrust into the most intolerable social and family situations. There he must ... present a face approximating the one associated with ordinary events and companionship. He must try to utter small talk and be responsive to questions, and knowingly nod, and frown and, God help him, even smile.

The writer's duty is to keep on writing.

I'm simply the happiest, the placidest, when I'm writing, and so I suppose that that, for me, is the final answer. ... It's fine therapy for people who are perpetually scared of nameless threats as I am most of the time.

Wickedly funny to read and morally bracing as only good satire can be.

my brain had begun to endure its familiar siege: panic and dislocation, and a sense that my thought processes were being engulfed by a toxic and unnameable tide that obliterated any enjoyable response to the living world.

A great book should leave you with many experiences.

I felt a kind of numbness, an enervation, but more particularly an odd fragility - as if my body had actually become frail, hypersensitive and somehow disjointed and clumsy, lacking normal coordination. And soon I was in the throes of a pervasive hypochondria.