The planet is populated by human beings, of which there are only two sexes, and the role of the writer is to explore otherness, other realities. So the idea of a man exploring what it's like to be a woman doesn't strike me as being that wild or crazy an idea.

science can only take you so far and then you have to leap

As for fame, fame felt like nothing. Fame was not a sensation like love or hunger or loneliness, welling from within and invisible to the outside eye. It was rather entirely external, coming from the minds of others. It existed in the way people looked at him or behaved towards him. In that, being famous was no different from being gay, or Jewish, or from a visible minority: you are who you are, and then people project onto you some notion they have.

My suffering left me sad and gloomy.

I turned around, stepped over the Zebra and threw myself overboard.

Fiction and nonfiction are not so easily divided. Fiction may not be real, but it's true; it goes beyond the garland of facts to get to emotional and psychological truths. As for nonfiction, for history, it may be real, but its truth is slippery, hard to access, with no fixed meaning bolted to it. If history doesn't become story, it dies to everyone except the historian.

A great literary work can be completely, completely unpredictable. Which can sometimes make them very hard to read, but it gives them a great originality.