We are not damned. We never were. Who under the sun has the right to damn any living breathing creature?

We’re going to die and not even know. We’ll never know, and all this meaninglessness will just go on and on and on. And we won’t any longer be witnesses to it. We won’t have even that little bit of power to give meaning to it in our minds. We’ll just be gone, dead, dead, dead, without ever knowing!

The whole theme of Interview with the Vampire was Louis's quest for meaning in a godless world. He searched to find the oldest existing immortal simply to ask, What is the meaning of what we are?

Don't be a fool for the Devil, darling.

It draws it's strength, this big secret, from the same root from which I draw my strength, both the good and the bad, because in the end, they cannot be separated.

But the sky was never quite the same shade of blue again.

It was over now, and the meaningless world was tolerable and need not be explained. And never would it be, and how foolish I had ever been to think so.