Wikipedia was a big help for science, especially science communication, and it shows no sign of diminishing in importance.

The biggest handicap in research is an ability to think outside the box. The handicap is being encumbered by all the conventional wisdom in a given field.

Accept the difficulty of what you cannot yet change. But do not accept the impossibility of ever changing it.

Theres no such thing as ageing gracefully. I dont meet people who want to get Alzheimers disease, or who want to get cancer or arthritis or any of the other things that afflict the elderly. Ageing is bad for you, and we better just actually accept that.

What I'm after is not living to 1,000. I'm after letting people avoid death for as long as they want to.

I dont often meet people who want to suffer cardiovascular disease or whatever, and we get those things as a result of the lifelong accumulation of various types of molecular and cellular damage.

The aim is to postpone frailty, postpone degenerative disease, debilitation and so on and thereby shorten the period at the end of life, which is passed in a decrepit or disabled state, while extending life as a whole.