The aim is to postpone frailty, postpone degenerative disease, debilitation and so on and thereby shorten the period at the end of life, which is passed in a decrepit or disabled state, while extending life as a whole.

Ever since we invented fire and the wheel, we've been demonstrating both our ability and our inherent desire to fix things that we don't like about ourselves and our environment.

The biggest handicap in research is an ability to think outside the box. The handicap is being encumbered by all the conventional wisdom in a given field.

Public enthusiasm for new advances is a key ingredient in influencing policy-makers to stimulate follow-up work with suitable funding, and it can be achieved far faster now that interested non-specialists can explore new research autonomously and can also be appealed to directly by scientists.

Wikipedia was a big help for science, especially science communication, and it shows no sign of diminishing in importance.

Basically, the body does have a vast amount of inbuilt anti-ageing machinery; it's just not 100% comprehensive, so it allows a small number of different types of molecular and cellular damage to happen and accumulate.

Some things tend not to work so well for science - things that rely on substantial written contributions by key experts are a case in point - but even there I tend to keep an open mind, because it may just be a case of finding the right formula.