Every attempt to employ mathematical methods in the study of chemical questions must be considered profoundly irrational and contrary to the spirit of chemistry.... if mathematical analysis should ever hold a prominent place in chemistry -- an aberration which is happily almost impossible -- it would occasion a rapid and widespread degeneration of that science.
Auguste ComteIn mathematics we find the primitive source of rationality; and to mathematics must the biologists resort for means to carry out their researches.
Auguste Comte