Physics is really nothing more than a search for ultimate simplicity, but so far all we have is a kind of elegant messiness.

As James Surowiecki noted in a New Yorker article, given a choice between developing antibiotics that people will take every day for two weeks and antidepressants that people will take every day for ever, drug companies not surprisingly opt for the latter. Although a few antibiotics have been toughened up a bit, the pharmaceutical industry hasn't given us an entirely new antibiotic since the 1970s.

For anyone of a rational disposition, fashion is often nearly impossible to fathom. Throughout many periods of history – perhaps most – it can seem as if the whole impulse of fashion has been to look maximally ridiculous. If one could be maximally uncomfortable as well, the triumph was all the greater.

Have you ever seen Glenn Beck in operation? It is the most terrifying thing. It's so bad that you think he's going to announce in a minute that it's all a great con. He makes Sarah Palin look reasonable and steady.

English is full of booby traps for the unwary foreigner. Any language where the unassuming word fly signifies an annoying insect, a means of travel, and a critical part of a gentleman's apparel is clearly asking to be mangled.

It is always quietly thrilling to find yourself looking at a world you know well but have never seen from such an angle before.

The great failure in education, much of the time, is the lack of excitement and stimulus