18th century scientists, the French in particular, seldom did things simply if an absurdly demanding alternative was available.

When I was growing up I used to think that the best thing about coming from Des Moines was that it meant you didn't come from anywhere else in Iowa. By Iowa standards, Des Moines is a mecca of cosmopolitanism, a dynamic hub of wealth and education, where people wear three-piece suits and dark socks, often simultaneously.

It was an especially wonderful time to be a noisy moron.

Every living thing is an elaboration of a single original plan. As humans we are mere increments - each of us a musty archive of adjustments, adaptations, modifications and providential tinkerings stretching back to 3,8 billion years. Remarkably we are even quite closely related to fruit and vegetables. About half the chemical functions that take place in a banana are fundamentally the same as the chemical functions that place in you. It cannot be said too often: all life is one. That is, and I suspect will ever prove to be, the most profound true statement there is.

If this book has a lesson, it is that we are awfully lucky to be here-and by 'we' I mean every living thing. To attain any kind of life in this universe of ours appears to be quite an achievement. As humans we are doubly lucky, of course: We enjoy not only the privilege of existence but also the singular ability to appreciate it and even, in a multitude of ways, to make it better. It is a talent we have only barely begun to grasp.

Germans are flummoxed by humor, the Swiss have no concept of fun, the Spanish think there is nothing at all ridiculous about eating dinner at midnight, and the Italians should never, ever have been let in on the invention of the motor car.

My first rule of travel is never to go to a place that sounds like a medical condition and Critz is clearly an incurable disease involving flaking skin.