Getting ready for a global pandemic is every bit as important as nuclear deterrence and avoiding a climate catastrophe.

Measuring programming progress by lines of code is like measuring aircraft building progress by weight.

For all these infectious diseases, the goal is to eventually get rid of them. And to do that we need to invent new tools, but nobody was doing that because there was no money to buy on behalf of the poorest, even the existing tools.

We have two other countries, Pakistan and Afghanistan - again it's the instability that is a problem there. So over the next several years, we expect to drive the number of [polio] cases back down to zero because that is likely to be the second disease after smallpox that we completely eradicate.

I never took a day off in my twenties. Not one.

Vision without execution is daydreaming.

When you write a piece of software you assume a certain type of hardware. If you assume hardware that's too powerful then you can't sell many copies cause very few people have that machine. If you assume hardware that's too simple your product can't do as much.