Software substitution, whether it's for drivers or waiters or nurses ... it's progressing. ... Technology over time will reduce demand for jobs, particularly at the lower end of skill set. ... 20 years from now, labor demand for lots of skill sets will be substantially lower. I don’t think people have that in their mental model.

These four policy prescriptions - strengthening educational opportunities, revamping immigration rules for highly skilled workers, increasing federal funding for basic scientific research, and providing incentives for private-sector R&D - should in my view be top priorities as Congress and the Administration consider how to maintain the nation's leadership in science, technology, and innovation.

When I was growing up, my parents were almost involved in various volunteer things. My dad was head of Planned Parenthood. And it was very controversial to be involved with that.

The computer was born to solve problems that did not exist before.

What destroys more self-confidence than any other educational thing in America is being assigned to some remedial math when you get into some college, and then it's not taught very well and you end up with this sense of, 'Hey, I can't really figure those things out.'

When I was young I liked taking tests. I happened to be good at it. Certain subjects came easily, like math. All the science stuff. I would just read the textbooks in the first few days of class.

We're creating this alliance, GAVI, that has helped buy the vaccines that were in the rich world but not getting to the poor kids, getting a very cheap price and figuring out the cold chain, getting the delivery right, and then funding research for new vaccines. A lot of them are coming along. We've got a meningitis vaccine out, got that through large parts of Africa. That has been a huge success.