The Global Fund is a central player in the progress being achieved on HIV, TB and malaria. It channels resources to help countries fight these diseases. I believe in its impact because I have seen it firsthand.

The most important 'speed' issue is often not technical but cultural. It's convincing everyone that the company's survival depends on everyone moving as fast as possible.

The obvious mathematical breakthrough would be development of an easy way to factor large prime numbers.

Having kids has been a fantastic thing for me. It's meant that I'm a little more balanced. In my twenties I worked massively, hardly took vacation at all. Now, I, with the help of my wife, I'm always making sure I've got a good balance of how I spend my time.

A lot of the things that will really improve the world fortunately aren't dependent on Washington doing something different.

My experience of malaria was just taking anti-malarials, which give you strange dreams, because I don't want to get malaria.

There was a magical breakthrough when the computer became cheap and we could see that everyone could afford a computer.