It’s been proven that of all the interventions to reduce poverty, improving agricultural productivity is the best.

I set a rule that people weren't allowed to send good news unless they sent around an equal amount of bad news. We had to get a balanced picture. In fact, I kind of favored just hearing about the accounts we were losing because ... bad news is generally more actionable than good news.

The potential financial reward for building the 'next Windows' is so great that there will never be a shortage of new technologies seeking to challenge it.

We're still missing about a dozen vaccines that will make a huge difference. For adults, we've got HIV and TB are still huge; for kids malaria is still killing a half million kids a year out of that 6 million. We probably need some vaccines, but we need a little more data to make sure we're getting the vaccines that will save the most lives.

Humanity’s greatest advances are not in its discoveries – but in how those discoveries are applied to reduce inequity. Whether through democracy, strong public education, quality health care, or broad economic opportunity – reducing inequity is the highest human achievement.

With polio, we've gone several years with no polio in all of Africa, but now with this we're having to go and mop up in that whole region, so it's a bit of a setback for polio. So in parallel we have to go back and get rid of those cases.

Today, you always know whether you are on the Internet or on your PC's hard drive. Tomorrow, you will not care and may not even know.