A placebo is a phony cure that works. This is very hard for the medical profession to get their teeth around because they hate placebos, but scientifically, placebos work in about 30% of cases that are psychogenic diseases.

A sign to me is a one-liner, a symbol is very complex and my house is a series of symbols.

Beautiful people are always with us, as evolutionary psychologists and a trip to the news-stand confirm.

The singular point of beautiful objects, and people, is that they are experienced not as parts, or ratios between cheekbones and chin, but as wholes. The experience of beauty is a perception, but it is one that mixes up various other sensations and makes them converge in a particular way.

Science is a victim of its own reductive metaphors: 'Big Bang,' 'selfish gene' and so on. Richard Dawkins' selfish gene fitted with the Thatcherite politics of the time. It should actually be the 'altruistic gene,' but he'd never have sold as many books with a title like that.

I'd been to Stourhead and was inspired by the perfect parity between architecture and art; in fact, the architecture is the art. I wrote a piece called 'Not Sculpture Park,' because most of these things become car parks for bought-in sculpture. The artists should be working with the site, not just plonking pieces down.

I've been a lucky man. I've only faced one real tragedy: the death of my wife, Maggie, from cancer in 1995.