Well, you know, I don't think anyone who writes a television series has a master plan from the beginning, and knows all the character traits, and everything that's going to happen.

Knowing that I'm not a model and I'm never going to be has relieved me of the pressure of looking good. If you don't establish yourself as McDreamy then you don't have to live up to it.

I didn’t know that it was going to launch a quote-unquote comedic career. I just wanted to do anything other than wait tables.

I don't think you should just do what makes you happy. Do what makes you great.

It is not elegant to gnaw Indian corn. The kernels should be scored with a knife, scraped off into the plate, and then eaten with a fork. Ladies should be particularly careful how they manage so ticklish a dainty, lest the exhibition rub off a little desirable romance.

There are times in your life when you feel like the dumbest man on the planet and you’re insecure about something, and then there are times where you feel like, “Hey, I’m a pretty smart guy and I’m pulling it together …”

Starting out, I bet I didn't get a lot of parts because of my strange voice. I'm not consciously thinking, 'Hey, sound like a squeaky dog toy mixed with a bagful of rusty nails.' It's just what my voice has done.