I don't think you should just do what makes you happy. Do what makes you great.

I didn’t know that it was going to launch a quote-unquote comedic career. I just wanted to do anything other than wait tables.

Knowing that I'm not a model and I'm never going to be has relieved me of the pressure of looking good. If you don't establish yourself as McDreamy then you don't have to live up to it.

You're happy that people are seeing your work. As for the critics, it really hurts when they knock you.

Starting out, I bet I didn't get a lot of parts because of my strange voice. I'm not consciously thinking, 'Hey, sound like a squeaky dog toy mixed with a bagful of rusty nails.' It's just what my voice has done.

I have expanded my mind and destroyed my liver but I didn't give up.

There are times in your life when you feel like the dumbest man on the planet and you’re insecure about something, and then there are times where you feel like, “Hey, I’m a pretty smart guy and I’m pulling it together …”