Spaceflight isn't just about doing experiments, it's about an extension of human culture.

To me, it's not about being anywhere, but being able to change my perceptions and experience something new.

Other anatomical changes associated with long-duration space flight are definitely negative: the immune system weakens, the heart shrinks because it doesn't have to strain against gravity, eyesight tends to degrade, sometimes markedly (no one's exactly sure why yet). The spine lengthens as the little sacs of fluid between the vertebrae expand, and bone mass decreases as the body sheds calcium. Without gravity, we don't need muscle and bone mass to support our own weight, which is what makes life in space so much fun but also so inherently bad for the human body, long-term.

Sweat the small stuff. Without letting anyone see you sweat.

It is spectacular. From about five minutes in, when we knew for sure that we were going to have the weather to go, the smile on my face just got bigger and bigger, and I was just beaming through the whole launch. I mean, it is just an amazing ride.

Still, I also know that most people, including me, tend to applaud the wrong things: the showy, dramatic record-setting sprint rather than the years of dogged preparation or the unwavering grace displayed during a string of losses. Applause, then, never bore much relation to the reality of my life as an astronaut, which was not all about, or even mostly about, flying around in space.

One Chief Astronaut used to make a point of phoning the front desk at the clinic where applicants are sent for medical testing, to find out which ones treated the staff well-and which ones stood out in a bad way. The nurses and clinic staff have seen a whole lot of astronauts over the years, and they know what the wrong stuff looks like. A person with a superiority complex might unwittingly, right there in the waiting room, quash his or her chances of ever going to space.