Most budget airlines anywhere in the world are going to leave you dissatisfied after using them.

I want to know: How does a space suit on Mars work? Show me how it is pressurized, and how it is cooled. What's the glove design? None of that stuff can be bought off the rack. It does not exist. You can't just go to SpaceMart and buy those things.

Other anatomical changes associated with long-duration space flight are definitely negative: the immune system weakens, the heart shrinks because it doesn't have to strain against gravity, eyesight tends to degrade, sometimes markedly (no one's exactly sure why yet). The spine lengthens as the little sacs of fluid between the vertebrae expand, and bone mass decreases as the body sheds calcium. Without gravity, we don't need muscle and bone mass to support our own weight, which is what makes life in space so much fun but also so inherently bad for the human body, long-term.

I've had a chance to fly a lot of different airplanes, but it was nothing like the shuttle ride.

"What's the next thing that's going to kill me?" is a mantra for pilots and astronauts.

The Nile, draining out into the Mediterranean. The bright lights of Cairo announce the opening of the north-flowing river’s delta, with Jerusalem’s answering high beams to the northeast. This 4,258 mile braid of human life, first navigated end-to-end in 2004, is visible in a single glance from space.

The rough and ready improvisational quality to life on board the International Space Station is reminiscent of a long trip in a sailboat: privacy and fresh produce are in short supply, hygiene is basic, and a fair amount of the crew's time is spent just on maintaining and repairing the craft.