Don't forget that you are the product of a culture that went stark raving mad about ten thousand years ago. Adjust your thinking accordingly.

We have all been given a gift with 'The Big Bang Theory,' a show that's not only based in the scientific community, but also enthusiastically supported by that same community - this is our opportunity to give back, in that spirit, our 'Big Bang' family has made a meaningful contribution, and together, we'll share in the support of these future scholars, scientists and leaders.

Life is never quite like the brochure.

It's safe to talk openly and honestly with people because they're not really listening.

I work from a deep sense of insecurity. I have the belief, and I can't shake it, that there are endless reasons to turn the channel. There are hundreds of channels and entirely other things to do besides TV. And if you make a bad television show there's no reason for the audience to come back the following week.

I'm an old guitar player who has fallen into television and is so happy he did.

I exercise regularly. I eat moderate amounts of healthy food. I make sure to get plenty of rest. I see my doctor once a year and my dentist twice a year. I floss every night. I've had chest x–rays, cardio stress tests, EKGs and colonoscopies. I see a psychologist and have a variety of hobbies to reduce stress. I don't drink. I don't smoke. I don't do drugs. I don't have crazy, reckless sex with strangers. If Charlie Sheen outlives me, I'm gonna be really pissed.