The only place where you can really surprise or shock the reader, or make someone laugh, is on the lower righthand corner - the very last panel - so as you turn the page, the payoff is in the upper lefthand panel. To pace every story so that there's a setup and a payoff at the page turn was a huge challenge; it's a part of the medium and you really have to learn what can be done in the medium.
Chuck PalahniukA hotel, he told me, was a big house where a lot of people lived and ate and slept, but no one knew each other. He said that described most families in the outside world.
Chuck PalahniukYou're safe because you're so trapped inside your culture. Anything you can conceive of is fine because you can conceive of it.
Chuck Palahniuk