Americans thinking that America will continue to lead the world in innovation and quality of life without some quick and serious educational improvements are dangerously delusional.

The word entrepreneur is associated with success and adventure. From my life, the only thing I can tell you that's consistently associated with entrepreneurship is failure, and the only thing consistently associated with invention is frustration. There is a long road between the idea and the reality.

What really makes it an invention is that someone decides not to change the solution to a known problem, but to change the question.

My biggest worry is I'm running out of time and energy. Thirty years ago I thought 10 years was a really long time.

I don't work on a project unless I believe that it will dramatically improve life for a bunch of people.

Most of the time you will fail, but you will also occasionally succeed. Those occasional successes make all the hard work and sacrifice worthwhile.

I think we have a society which is spending more and more of its money on healthcare as a percent of GDP as a percent of a lot of things. I think that's a measure of success.