Why the hell hasn't wxPython become the standard GUI for Python yet?

The next best thing to having good ideas is recognizing good ideas from your users. Sometimes the latter is better.

Release early. Release often. And listen to your customers.

The combination of threads, remote-procedure-call interfaces, and heavyweight object-oriented design is especially dangerous... if you are ever invited onto a project that is supposed to feature all three, fleeing in terror might well be an appropriate reaction.

The only way to write complex software that won't fall on its face is to hold its global complexity down - to build it out of simple pieces connected by well-defined interfaces, so that most problems are local and you can have some hope of fixing or optimizing a part without breaking the whole

Thompson and Ritchie were among the first to realize that hardware and compiler technology had become good enough that an entire operating system could be written in C, and by 1978 the whole environment had been successfully ported to several machines of different types.

When your language is nowhere near Turing-complete, syntactic sugar can be your friend.