I tried to be a ski bum when I stepped away from Twitter, and I wasn't a very good skier.

Failure of your company is not failure in life. Failure in your relationships is.

Take a human desire, preferably one that has been around for a really long time Identify that desire and use modern technology to take out steps.

User experience is everything. It always has been, but it's undervalued and underinvested in. If you don't know user-centered design, study it. Hire people who know it. Obsess over it. Live and breathe it. Get your whole company on board.

Take care of yourself: When you don't sleep, eat crap, don't exercise, and are living off adrenaline for too long, your performance suffers. Your decisions suffer. Your company suffers. Love those close to you: Failure of your company is not failure in life. Failure in your relationship is.

The things that keep nagging at you are the ones worth exploring.

I suspect there's a lot of validity to the premise that big companies aren't going to attract entrepreneurial talent.