Change the world. Build a business. Have fun.

Take care of yourself: When you don't sleep, eat crap, don't exercise, and are living off adrenaline for too long, your performance suffers. Your decisions suffer. Your company suffers. Love those close to you: Failure of your company is not failure in life. Failure in your relationship is.

Assume the best but hire paranoid people.

When you’re obsessing about one thing, you can reach insights about how to solve hard problems. If you have too many things to think about, you’ll get to the superficial solution, not the brilliant one.

The vast majority of things are distractions, and very few really matter to your success.

When I meet with the founders of a new company, my advice is almost always, ‘Do fewer things.’ It’s true of partnerships, marketing opportunities, anything that’s taking up your time. The vast majority of things are distractions, and very few really matter to your success.

I tried to be a ski bum when I stepped away from Twitter, and I wasn't a very good skier.