Assume the best but hire paranoid people.

The vast majority of things are distractions, and very few really matter to your success.

When you’re obsessing about one thing, you can reach insights about how to solve hard problems. If you have too many things to think about, you’ll get to the superficial solution, not the brilliant one.

I tried to be a ski bum when I stepped away from Twitter, and I wasn't a very good skier.

Failure of your company is not failure in life. Failure in your relationships is.

Change the world. Build a business. Have fun.

User experience is everything. It always has been, but it's undervalued and underinvested in. If you don't know user-centered design, study it. Hire people who know it. Obsess over it. Live and breathe it. Get your whole company on board.