For simplicity one can think of the + class as having one extra base at some point or other in the genetic message and the - class as having one too few.
Francis CrickIf the code does indeed have some logical foundation then it is legitimate to consider all the evidence, both good and bad, in any attempt to deduce it.
Francis CrickOur ... advantage was that we had evolved unstated but fruitful methods of collaboration ... If either of us suggested a new idea, the other, while taking it seriously, would attempt to demolish it in a candid but non-hostile manner.
Francis CrickMoreover the incorporation requires the same components needed for protein synthesis, and is inhibited by the same inhibitors. Thus the system is most unlikely to be a complete artefact and is very probably closely related to genuine protein synthesis.
Francis Crick