Unfortunately it makes the unambiguous determination of triplets by these methods much more difficult than would be the case if there were only one triplet for each amino acid.
Francis CrickFor simplicity one can think of the + class as having one extra base at some point or other in the genetic message and the - class as having one too few.
Francis CrickWhen you start in science, you are brainwashed into believing how careful you must be, and how difficult it is to discover things. There's something that might be called the 'graduate student syndrome'; graduate students hardly believe they can make a discovery.
Francis CrickWhat could be more foolish than to base one's entire view of life on ideas that, however plausible at the time, now appear to be quite erroneous? And what would be more important than to find our true place in the universe by removing one by one these unfortunate vestiges of earlier beliefs?
Francis Crick