If poly A is added to poly U, to form a double or triple helix, the combination is inactive.
Francis CrickHaemoglobin is a very large molecule by ordinary standards, containing about ten thousand atoms, but the chances are that your haemoglobin and mine are identical, and significantly different from that of a pig or horse. You may be impressed by how much human beings differ from one another, but if you were to look into the fine details of the molecules of which they are constructed, you would be astonished by their similarity.
Francis CrickProtein synthesis is a central problem for the whole of biology, and that it is in all probability closely related to gene action.
Francis CrickIt now seems certain that the amino acid sequence of any protein is determined by the sequence of bases in some region of a particular nucleic acid molecule.
Francis CrickFinally one should add that in spite of the great complexity of protein synthesis and in spite of the considerable technical difficulties in synthesizing polynucleotides with defined sequences it is not unreasonable to hope that all these points will be clarified in the near future, and that the genetic code will be completely established on a sound experimental basis within a few years.
Francis Crick