Ideas that most people derided as ridiculous have produced the best outcomes. Don't do the obvious thing.

We need new medical approaches to preventing and/or curing disease. We need new scientific approaches to generating, storing, and being more efficient with energy. Maybe we need more space exploration. Maybe we need more undersea exploration.

There is a difference between hiring a CEO and turning over control of the business.

Facebook is not an unstoppable juggernaut. There are a lot of other things people can do on the web.

It's not easy for an entrepreneur to find the time to blog. But for those who do it, it is a great tool to communicate with the various stakeholders in their business and build a reputation for thought leadership.

Don't try to solve the entire problem on day one.

When I see people laughing at ideas and companies we have backed, I smile. It means we are going to make a lot of money on that investment.