I played a father a few times. You don't have to shoot heroin to play a heroin addict ... I'm not running for president but I could play a candidate. Most of the time, you don't really have to have those things in your life to understand what they're like.

In 2003 I was saying, where are the ties [between Iraq] and al-Qaida? Where are the ties to 9/11? I knew it; where the f**k were these Democrats who said, 'We were misled'? That's the kind of thing that drives me crazy: 'We were misled.' F**k you, you weren't misled. You were afraid of being called unpatriotic.

I've been lucky enough to do a few films that will last longer than an opening weekend and those films are the ones I'm proud of.

I've been left for someone...all those things...It was sometimes a surprise, and sometimes you saw t coming. The most painful was when I kept trying to get someone back. But we all make dumb mistakes.

I've been in relationships where I've felt terribly alone. Just because you're with someone, it doesn't mean you're happy.

It is not lost on me that I'm spending my honeymoon at Comic Con.

After doing One Fine Day and playing a pediatrician on ER, I'll never have kids. I'm going to have a vasectomy.