Now, almost twenty years since my last job in book publishing, I know that there are far more socially inept people in book than in magazine publishing. At the time, however, I just didn't feel I was enough: smart enough, savvy enough, well read enough, educated enough, charming enough. Much of this was probably because I was very naive, and didn't really know how to behave in an office. This made me a terrible assistant, which in turn made me a terrible junior book editor.

I credit my parents for many things that had never seemed remarkable when I was growing up, and one of those things is how nonthreatened they were by my constant search for backup parents - other mothers and fathers would have bristled at this, but they never did. So I was always looking for other parental stand-ins, and I always found them.

I'm not sure a person ever really reveals the whole of himsels or herself to another person, and I'm not sure we should. Or rather, just because you don't, it doesn't mean you can't have a meaningful relationship with another person. It's important to remember that this idea of confessing your most shameful, embarrassing stories and self to someone else as an expression of love and intimacy is a relatively recent phenomenon, and a new definition of what it means to be close to someone. After all, the self is by its nature secretive.

I always wanted to be a scientist. I don't really have any writer friends. The process of being a writer is much more interior than being a scientist, because science is so reactionary. I think that all research scientists think of themselves as belonging to a grand tradition, building on work that has been worked on since the very beginning of science itself. Whereas I'm not sure writers think of themselves in the same way.

To be a scientist you have to be willing to live with uncertainty for a long time. Research scientists begin with a question and they take a decade or two to find an answer. Then the answer they get may not even answer the question they thought it would. You have to have a supple enough mind to be open to the possibility that the answer sometimes precedes the question itself.

If you start asking how do we make life meaningful and life never ends, then you get into sort of these terrible sort of metaphysical quandaries and it gets really, really bleak looking.

I've never really understood the desire to be immortal myself. The idea of both wanting to live forever in some form and wanting to stay young forever just sounds exhausting. It's one of those desires that people think they want but when you actually stop to think about what it actually means, it's really awful. One of the reasons that life is bearable is because it's going to end soon. One of the main concerns of fiction is how do we make a life of 85 years or so meaningful.