When you're young, your perception of what it means to be a writer is often less about the writing and more about what seems to be the accompanying life: speeches and travel and hanging out with other writers. You think that when you get published, your life will clarify itself to you somehow. But when you don't get published until you're middle-aged you know who you are already, and your life expands to make room for your writing, rather than orbiting around it. You realize that there's no one way to be a writer, and that the job is less of an identity and more of a vocation.

To be a scientist you have to be willing to live with uncertainty for a long time. Research scientists begin with a question and they take a decade or two to find an answer. Then the answer they get may not even answer the question they thought it would. You have to have a supple enough mind to be open to the possibility that the answer sometimes precedes the question itself.

The big characters who occupy science, especially modern science, are all "off" in fundamental ways. I don't think that genius goes hand in hand with being socially inept or being a sociopath or being a misanthrope, but I do think that it is a mind that can think so differently - so beyond how one is supposed to think. I wanted to pay tribute to that mind.

It is always sort of unnerving to hear from people who've read my books. I'm not reading any of the reviews and most of my friends haven't read it - they bought it, which is all I frankly care about, but they haven't read it.

Many writers hate the shilling process, and I understand that. However, it's really the only thing about the publication process you can somewhat control. You can't affect reviews. But you can try to find your book an audience. One of the problems with the book publishing industry is that their publicity efforts tend to be spent on people who already read, and know how to discover, literary fiction.

When you never leave the literary biosphere, you forget how few people actually read books, and that in turn makes you start overestimating both your ability to make money and your relative renown, which has dangerous consequences: the first means you may end up in debt; the second means you may end up a horrid bore.

We're living in a literary age, at least in America, that is marked by a sense of distance, a coolness, in all senses of that word. To be too obviously, unapologetically emotional is to risk being considered foolish, or at the very least not serious.