Witing is essentially interior work, and many writers are interior personalities. Having a job forces you out of the world of your work, and into the one in which you get to observe people. Yes, you can imagine all this, but as a fiction writer, you can never observe enough the rhythms of how humans move through the world. A job demands that you structure your time much more carefully. You learn how to be resourceful, and that in turn provides a certain intensity of focus.

To be a scientist you have to be willing to live with uncertainty for a long time. Research scientists begin with a question and they take a decade or two to find an answer. Then the answer they get may not even answer the question they thought it would. You have to have a supple enough mind to be open to the possibility that the answer sometimes precedes the question itself.

There are times I wish I didn't have a job, even though I love my job: I get to work with interesting, eccentric colleagues and equally interesting and eccentric subject matter, both of which are rarities. But, naturally, I would treasure having more freedom someday: of time and of movement. Will I always have a full-time job? I don't know. But I do know that I need to spend at least part of my week in an office, with other people.

I know I'm a better editor than I was when I began, twenty years ago. I'm less scared of the text, I'm less scared of the writer, and, crucially, I no longer believe that I have to leave my mark on every story.

I wanted to write about the time when science became modern, around the 1950s. Right after physicist J. Robert Oppenheimer, science started being so politicized and used as such a political weapon. When my father, who is a scientist, tells me about those years, I get a competing portrait of people who were expected to behave normally and be decent respectable members of society and who were also allowed this freedom to think in big and expansive ways. Now, when you think about people who work in labs, they're allowed to be socially inept in a very fundamental way.

Many writers write across difference of one kind or another. Sometimes the difference is large and recognizable: gender, or race, or religion, or sexuality. And sometimes the differences are smaller. ... Where authors get into trouble is in trying to make those different characters stand in for whole groups of people, or for creating characters only to fetishize or explore their supposed otherness. Your character can be wildly different from you, as long as he's written with respect and, moreover, specificity.

I'm not sure a person ever really reveals the whole of himsels or herself to another person, and I'm not sure we should. Or rather, just because you don't, it doesn't mean you can't have a meaningful relationship with another person. It's important to remember that this idea of confessing your most shameful, embarrassing stories and self to someone else as an expression of love and intimacy is a relatively recent phenomenon, and a new definition of what it means to be close to someone. After all, the self is by its nature secretive.