Many writers write across difference of one kind or another. Sometimes the difference is large and recognizable: gender, or race, or religion, or sexuality. And sometimes the differences are smaller. ... Where authors get into trouble is in trying to make those different characters stand in for whole groups of people, or for creating characters only to fetishize or explore their supposed otherness. Your character can be wildly different from you, as long as he's written with respect and, moreover, specificity.

The big characters who occupy science, especially modern science, are all "off" in fundamental ways. I don't think that genius goes hand in hand with being socially inept or being a sociopath or being a misanthrope, but I do think that it is a mind that can think so differently - so beyond how one is supposed to think. I wanted to pay tribute to that mind.

To be a scientist you have to be willing to live with uncertainty for a long time. Research scientists begin with a question and they take a decade or two to find an answer. Then the answer they get may not even answer the question they thought it would. You have to have a supple enough mind to be open to the possibility that the answer sometimes precedes the question itself.

We're living in a literary age, at least in America, that is marked by a sense of distance, a coolness, in all senses of that word. To be too obviously, unapologetically emotional is to risk being considered foolish, or at the very least not serious.

There are times I wish I didn't have a job, even though I love my job: I get to work with interesting, eccentric colleagues and equally interesting and eccentric subject matter, both of which are rarities. But, naturally, I would treasure having more freedom someday: of time and of movement. Will I always have a full-time job? I don't know. But I do know that I need to spend at least part of my week in an office, with other people.

I was fortunate because I had parents who believed that being a writer was a perfectly acceptable thing to want to be. They'd actually hoped that I might be an artist, and I was lucky again to grow up with people who delighted in making things: my father wove baskets and painted furniture and carved wood figures; my mother quilted and embroidered and sewed.

I wanted to write about the time when science became modern, around the 1950s. Right after physicist J. Robert Oppenheimer, science started being so politicized and used as such a political weapon. When my father, who is a scientist, tells me about those years, I get a competing portrait of people who were expected to behave normally and be decent respectable members of society and who were also allowed this freedom to think in big and expansive ways. Now, when you think about people who work in labs, they're allowed to be socially inept in a very fundamental way.