When you never leave the literary biosphere, you forget how few people actually read books, and that in turn makes you start overestimating both your ability to make money and your relative renown, which has dangerous consequences: the first means you may end up in debt; the second means you may end up a horrid bore.

The big characters who occupy science, especially modern science, are all "off" in fundamental ways. I don't think that genius goes hand in hand with being socially inept or being a sociopath or being a misanthrope, but I do think that it is a mind that can think so differently - so beyond how one is supposed to think. I wanted to pay tribute to that mind.

Much of an editor's job is in fact pretty nanny-like in nature: in many ways, you're there to protect and defend, to reassure and clean up. What I ask from writers is respect. I want them to respect me enough to turn in a clean draft. I want that draft to be as good as they can make it. I want to feel the thought behind those words. And I want it to be turned in on time. It drives me wild when I get a story that's obviously slapped together, and the same can be said for a manuscript; you should respect your reader enough to give her something that reflects your best efforts.

I credit my parents for many things that had never seemed remarkable when I was growing up, and one of those things is how nonthreatened they were by my constant search for backup parents - other mothers and fathers would have bristled at this, but they never did. So I was always looking for other parental stand-ins, and I always found them.

When you want to be a writer, you think that actually getting published will make you feel somehow more real to yourself. But it doesn't. And nor should it. If publication is the pole around which your entire identity pivots, you're in big trouble. I'd also add that many wonderful books by brilliant authors get ignored or overlooked, and that poor sales aren't (necessarily) a measure of your abilities.

I'm an indulgent writer - I'm not sure, however, that's something I'm interested in changing. Writing should be indulgent: you should take big risks on the page, you should make big mistakes, you should be excessive at times. I let myself do as a writer what I probably would be less likely to allow as an editor.

I have one friend to whom I've told more than I've ever told anyone, and yet there are significant territories I have and will never let him access - in large part because I'm trying to protect him, and one of the responsibilities of loving someone is protecting him or her, even if who you're protecting them from is yourself.