When you're 21 you think, "Old people sound like this. Old people think like this." I don't think my ideas about aging and about eternal life changed that much, but it became more poignant to me as I did get older and I could better imagine, as you sort of inch closer to death every day, why legacy, more than aging, becomes important to people.

I know I'm a better editor than I was when I began, twenty years ago. I'm less scared of the text, I'm less scared of the writer, and, crucially, I no longer believe that I have to leave my mark on every story.

Of death, my father has always said that the best conditions are the ones in which you have plenty of time to prepare - to say what you need to say; to arrange your estate - and the ones in which you get to choose, or at least have some knowledge of, how and when it might happen. One can't elude death, but one can have a good death.

I credit my parents for many things that had never seemed remarkable when I was growing up, and one of those things is how nonthreatened they were by my constant search for backup parents - other mothers and fathers would have bristled at this, but they never did. So I was always looking for other parental stand-ins, and I always found them.

Many writers hate the shilling process, and I understand that. However, it's really the only thing about the publication process you can somewhat control. You can't affect reviews. But you can try to find your book an audience. One of the problems with the book publishing industry is that their publicity efforts tend to be spent on people who already read, and know how to discover, literary fiction.

Much of an editor's job is in fact pretty nanny-like in nature: in many ways, you're there to protect and defend, to reassure and clean up. What I ask from writers is respect. I want them to respect me enough to turn in a clean draft. I want that draft to be as good as they can make it. I want to feel the thought behind those words. And I want it to be turned in on time. It drives me wild when I get a story that's obviously slapped together, and the same can be said for a manuscript; you should respect your reader enough to give her something that reflects your best efforts.

I wanted to write about the time when science became modern, around the 1950s. Right after physicist J. Robert Oppenheimer, science started being so politicized and used as such a political weapon. When my father, who is a scientist, tells me about those years, I get a competing portrait of people who were expected to behave normally and be decent respectable members of society and who were also allowed this freedom to think in big and expansive ways. Now, when you think about people who work in labs, they're allowed to be socially inept in a very fundamental way.