A lot of comedy clubs are set up with people sitting at little tables and you have everything from the way they are seated to them ordering or taking a sip of a drink, these can make a comedian go harder and faster in a club.

I never turn on the crowd. Sometimes, you think it's a terrible show, and then afterward, sometimes people say they really liked it. So turning on the crowd is only going to alienate the few people who might like it.

With the first episode [of John Mulaney Show] I tell a story that happened to me accidentally chasing a woman down the subway.

That was an interesting thing I learned I think the first time I did a late night show or something. It was like, "Oh, this is for the camera and a performance that you're giving to the people at home."

I remember writing standup jokes without having done sets. But as soon as I did my first set, it didn't matter. Everything I thought would work didn't work. And everything I was iffy on was funny.

"The Doula" was and is a very, very special episode to me because I think it's very funny and very weird and it also is 100 percent based on my life, in that I fainted three times during Sex Ed in real life the three different years.

My standup persona is like I'll heighten things, but I'm observing the world as it is in sort of a heightened emotional state.