Whenever a theory appears to you as the only possible one, take this as a sign that you have neither understood the theory nor the problem which it was intended to solve.

Man, some modern philosophers tell us, is alienated from his world: he is a stranger and afraid in a world he never made. Perhaps he is; yet so are animals, and even plants. They too were born, long ago, into a physico-chemical world, a world they never made.

It is easy to obtain confirmations, or verifications, for nearly every theory-if we look for confirmations. Confirmations should count only if they are the result of risky predictions... A theory which is not refutable by any conceivable event is non-scientific. Irrefutability is not a virtue of a theory (as people often think) but a vice. Every genuine test of a theory is an attempt to falsify it, or refute it.

We should realize that, if [Socrates] demanded that the wisest men should rule, he clearly stressed that he did not mean the learned men; in fact, he was skeptical of all professional learnedness, whether it was that of the philosophers or of the learned men of his own generation, the Sophists. The wisdom he meant was of a different kind. It was simply the realization: how little do I know! Those who did not know this, he taught, knew nothing at all. This is the true scientific spirit.

We know a great deal, but our ignorance is sobering and boundless. With each step forward, with each problem which we solve, we not only discover new and unsolved problems, but we also discover that where we believed that we were standing on firm and safe ground, all things are, in truth, insecure and in a state of flux.

Better our hypotheses die for our errors than ourselves.

A theory which is not refutable by any conceivable event is non-scientific. Irrefutability is not a virtue of a theory (as people often think) but a vice.