Minnesotans really think they run the whole world, I love that.

When I say, 'I can't stay long, I'm in-between meals,' that plays differently on the radio than it does in person. So I have to pick material that works because the words are funny, not just because of the images.

My mom ate every piece of butter in the Midwest, she lived till she was 90. And my dad, he smoked, he drank - we finally just had to kill him.

I really made the cartoon Life with Louie with one reason in mind: I didn't have a very good relationship with my dad, and we didn't all watch TV together like we should've, like you hope for, like you've seen on TV, and I wanted to make it for moms and dads and their kids. That was always my goal. And then I wanted to put real things in it. We did a thing about the homeless and won a Humanitas award for that.

I'll tell you how you know when you're on something good: when everybody starts to tear up when they're leaving, when they're wrapping for the season. You know, when you say, "All right, we're done with McGillicuddy. That's a wrap for McGillicuddy!" And everybody applauds, but everybody's sad, because McGillicuddy's going to be gone! You know, it's like family going off to college or war. You have this intimate relationship with these people, and then - bam! - they're gone.

It's so much easier to be cynical.

I have to be very careful about how I do any stuff on sadness 'cause the crowd gets really sad and concerned for me.