Some of the big philosophical problems have been solved by science, at least to a 1st approximation. Examples: the problems of matter, and mind. Only philosophical reactionaries, like Noam Chomsky, claim that they are and will remain mysteries.

Of course you cannot free yourself from the laws of nature; but the laws of nervous systems are not the same as the physical laws.

We deem valuable whatever is likely to meet our needs or wishes (individual values) and whatever is likely to help protect or attain social goals (social values). However, this is not a dichotomy, for some individual values, such as truth, are needed to secure some social values, such as mutual trust, and some social values, such as peace, are required to pursue some individual values, such as good health.

One should believe only what can be chosen to be true or just. Irrational (or unjustified) beliefs should be avoided because they can have disastrous practical consequences.

From a historical viewpoint, religion is just a kind of superstition, and from a political viewpoint it is a tool of social control.

Of course much remains to know, but we know how to learn: through scientific research.

Even philosophies who have denounced pseudosciences like psychoanalysis, have condoned pseudoscientific economic theories like neoclassical microeconomics. It is far safer and easier to criticize Freud and Jung than to criticize Milton Friedman and Friedrich Hayek, because the latter are backed by political movements whereas the former are not.