I am guided by the vision of what I believe this show can be. Originally our goal was to uplift, enlighten, encourage and entertain through the medium of television. Now, our mission statement for The Oprah Winfrey Show is to use television to transform people's lives, to make viewers see themselves differently and to bring happiness and a sense of fulfillment into every home.

I would say that during the time that I was 14 and pregnant - I didn't even know what pregnancy was when I got pregnant - I was trying to do everything I could to harm myself. I said to God, "God, if you want me to die, then you're going to have to kill me".

Great communication begins with connection.

I’ve learned not to worry about what might come next.

One of the biggest lessons I've learned recently is that when you don't know what to do, you should do nothing until you figure out what to do because a lot of times you feel like you are pressed against the wall, and you've got to make a decision. You never have to do anything. Don't know what to do? Do nothing.

Often intuition will direct you. If it feels right, it's probably right.

You are responsible for your life. It doesn't matter what your Mama did. It doesn't matter what your Daddy didn't do. You are responsible for your life.