People sometimes mistake being serious with being taken seriously.

When I left Maine, I always wanted to be a working actor. I never cared too much about being the star. I just wanted to do the work and get on with it.

My wife and I try not to get into each other's work too much.

The worst part about being married is when you're not connecting. Your partner is going out the door when you're coming in, and you don't have a chance to debrief on the day. That's the worst.

I was 17 when I left the small Maine town where I'd grown up. I wanted to do something I thought was important with my life, so I headed to California and didn't look back.

Now I'm just known as McDreamy, I've lost all identity as Patrick Dempsey, I'm now McDreamy.

Drama is easier to do because you just have to have the emotion and not get caught acting, but comedy is much harder.