To deride the hope of progress is the ultimate fatuity, the last word in poverty of spirit and meanness of mind.

It goes with the passionate intensity and deep conviction of the truth of a religious belief, and of course of the importance of the superstitious observances that go with it, that we should want others to share it - and the only certain way to cause a religious belief to be held by everyone is to liquidate nonbelievers. The price in blood and tears that mankind generally has had to pay for the comfort and spiritual refreshment that religion has brought to a few has been too great to justify our entrusting moral accountancy to religious belief.

It is high time that laymen abandoned the misleading belief that scientific enquiry is a cold dispassionate enterprise, bleached of imaginative qualities, and that a scientist is a man who turns the handle of discovery; for at every level of endeavour scientific research is a passionate undertaking and the Promotion of Natural Knowledge depends above all on a sortee into what can be imagined but is not yet known.

It is a common failing-and one that I have myself suffered from-to fall in love with a hypothesis and to be unwilling to take no for an answer. A love affair with a pet hypothesis can waste years of precious time. There is very often no finally decisive yes, though quite often there can be a decisive no.

It is a truism to say that a good experiment is precisely that which spares us the exertion of thinking: the better it is, the less we have to worry about its interpretation, about what it really means.

I shall borrow two words used for a slightly different purpose by the great demographer Alfred Lotka to distinguish between the two systems of heredity enjoyed by man: endosomatic or internal heredity for the ordinary or genetical heredity we have in common with animals; and exosomatic or external heredity for the non-genetic heredity that is peculiarly our own - the heredity that is mediated through tradition, by which I mean the transfer of information through non-genetic channels from one generation to the next.

Twice in my life I have spent two weary and scientifically profitless years seeking evidence to corroborate dearly loved hypotheses that later proved to be groundless; times such as these are hard for scientists-days of leaden gray skies bringing with them a miserable sense of oppression and inadequacy.