It is the great glory as well as the great threat of science that everything which is in principle possible can be done if the intention to do it is sufficiently resolute.

Scientific reasoning is a dialogue between the possible and the actual, between proposal and disposal between what might be true, and what is in fact the case.

I reckon that for all the use it has been to science about four-fifths of my time has been wasted, and I believe this to be the common lot of people who are not merely playing follow-my-leader in research.

You have ... been told that science grows like an organism. You have been told that, if we today see further than our predecessors, it is only because we stand on their shoulders. But this [Nobel Prize Presentation] is an occasion on which I should prefer to remember, not the giants upon whose shoulders we stood, but the friends with whom we stood arm in arm ... colleagues in so much of my work.

Psychoanalytic theory is the most stupendous intellectual confidence trick of the twentieth century and a terminal product as well-something akin to a dinosaur or zeppelin in the history of ideas, a vast structure of radically unsound design and with no posterity.

We cannot point to a single definitive solution of any one of the problems that confront us — political, economic, social or moral, that is, having to do with the conduct of life. We are still beginners, and for that reason may hope to improve. To deride the hope of progress is the ultimate fatuity, the last word in poverty of spirit and meanness of mind. There is no need to be dismayed by the fact that we cannot yet envisage a definitive solution of our problems, a resting-place beyond which we need not try to go.

[A certain class of explanations in science are] analgesics that dull the ache of incomprehension without removing the cause.