All scientists know of colleagues whose minds are so well equipped with the means of refutation that no new idea has the temerity to seek admittance. Their contribution to science is accordingly very small.

No scientist is admired for failing in the attempt to solve problems that lie beyond his competence. ... Good scientists study the most important problems they think they can solve. It is, after all, their professional business to solve problems, not merely to grapple with them.

For a scientist must indeed be freely imaginative and yet skeptical, creative and yet a critic. There is a sense in which he must be free, but another in which his thought must be very preceisely regimented; there is poetry in science, but also a lot of bookkeeping.

The bells which toll for mankind are - most of them, anyway - like the bells of Alpine cattle; they are attached to our own necks, and it must be our fault if they do not make a cheerful and harmonious sound.

I regret my disbelief in God.

If a person is A) poorly, B) receives treatment intended to make him better, and C) gets better, then no power of reasoning known to medical science can convince him that it may not have been the treatment that restored his health.

The art of research [is] the art of making difficult problems soluble by devising means of getting at them.