Considered in its entirety, psychoanalysis won't do. It is an end product, moreover, like a dinosaur or a zeppelin; no better theory can ever be erected on its ruins, which will remain for ever one of the saddest and strangest of all landmarks in the history of twentieth century thought.

The fact that scientists do not consciously practice a formal methodology is very poor evidence that no such methodology exists. It could be said-has been said-that there is a distinctive methodology of science which scientists practice unwittingly, like the chap in Moliere who found that all his life, unknowingly, he had been speaking prose.

I cannot give any scientist of any age better advice than this: the intensity of a conviction that a hypothesis is true has no bearing over whether it is true or not.

It goes with the passionate intensity and deep conviction of the truth of a religious belief, and of course of the importance of the superstitious observances that go with it, that we should want others to share it - and the only certain way to cause a religious belief to be held by everyone is to liquidate nonbelievers. The price in blood and tears that mankind generally has had to pay for the comfort and spiritual refreshment that religion has brought to a few has been too great to justify our entrusting moral accountancy to religious belief.

[A certain class of explanations in science are] analgesics that dull the ache of incomprehension without removing the cause.

I once spoke to a human geneticist who declared that the notion of intelligence was quite meaningless, so I tried calling him unintelligent. He was annoyed, and it did not appease him when I went on to ask how he came to attach such a clear meaning to the notion of lack of intelligence. We never spoke again.

Twice in my life I have spent two weary and scientifically profitless years seeking evidence to corroborate dearly loved hypotheses that later proved to be groundless; times such as these are hard for scientists-days of leaden gray skies bringing with them a miserable sense of oppression and inadequacy.