If a scientist were to cut his ear off, no one would take it as evidence of a heightened sensibility.

The art of research [is] the art of making difficult problems soluble by devising means of getting at them.

You have ... been told that science grows like an organism. You have been told that, if we today see further than our predecessors, it is only because we stand on their shoulders. But this [Nobel Prize Presentation] is an occasion on which I should prefer to remember, not the giants upon whose shoulders we stood, but the friends with whom we stood arm in arm ... colleagues in so much of my work.

Is the Scientific Paper a Fraud?

The human mind treats a new idea the same way the body treats a strange protein; it rejects it.

The bells which toll for mankind are - most of them, anyway - like the bells of Alpine cattle; they are attached to our own necks, and it must be our fault if they do not make a cheerful and harmonious sound.

It is a common failing-and one that I have myself suffered from-to fall in love with a hypothesis and to be unwilling to take no for an answer. A love affair with a pet hypothesis can waste years of precious time. There is very often no finally decisive yes, though quite often there can be a decisive no.