Innocent, unbiased observation is a myth.

No scientist is admired for failing in the attempt to solve problems that lie beyond his competence. ... Good scientists study the most important problems they think they can solve. It is, after all, their professional business to solve problems, not merely to grapple with them.

You have ... been told that science grows like an organism. You have been told that, if we today see further than our predecessors, it is only because we stand on their shoulders. But this [Nobel Prize Presentation] is an occasion on which I should prefer to remember, not the giants upon whose shoulders we stood, but the friends with whom we stood arm in arm ... colleagues in so much of my work.

The bells which toll for mankind are - most of them, anyway - like the bells of Alpine cattle; they are attached to our own necks, and it must be our fault if they do not make a cheerful and harmonious sound.

It is a truism to say that a good experiment is precisely that which spares us the exertion of thinking: the better it is, the less we have to worry about its interpretation, about what it really means.

I once spoke to a human geneticist who declared that the notion of intelligence was quite meaningless, so I tried calling him unintelligent. He was annoyed, and it did not appease him when I went on to ask how he came to attach such a clear meaning to the notion of lack of intelligence. We never spoke again.

It can be said with complete confidence that any scientist of any age who wants to make important discoveries must study important problems. Dull or piffling problems yield dull or piffling answers. It is not enough that a problem should be "interesting".